Product Description
124Triazolo43apyridine32Hone is a heterocyclic compound with a fused triazolopyridine structure often of interest in medicinal and materials chemistry Below is a detailed description
Chemical Information
- Chemical Name 124Triazolo43apyridine32Hone
- Chemical Formula C6H5N3O
- Molecular Weight 13512 gmol
Structure
- A fused bicyclic system consisting of a pyridine ring and a 124triazole ring
- A ketone group O is located at the 3rd position of the triazole ring
- The compound exists in a tautomeric equilibrium between keto and enol forms depending on environmental conditions
Physical Properties
- Appearance White to pale yellow crystalline solid
- Melting Point Around 200250C depending on substituents and purity
Solubility
- Soluble in polar solvents like dimethyl sulfoxide DMSO and methanol
- Slightly soluble in water
Applications
Pharmaceutical Industry
- The triazolopyridine scaffold is widely used in designing bioactive molecules such as antiviral antibacterial antifungal or anticancer agents
- Known to interact with enzymes or receptors due to its planar and electronrich structure
Chemical Synthesis
- Used as a precursor or intermediate in synthesizing more complex heterocyclic compounds
- Offers a platform for functionalization at the pyridine and triazole rings
Materials Science: Investigated for optoelectronic and photophysical properties in the development of advanced materials like organic semiconductors or lightemitting diodes LEDs
Reactivity
- Functional Groups
- Ketone Group CO Reactive in nucleophilic addition or condensation reactions
- Triazole Ring Stable under most conditions but can participate in substitutions at activated positions
- Pyridine Ring Capable of electrophilic or nucleophilic aromatic substitutions
Tautomerism
Can exist as ketoenol tautomers with the equilibrium influenced by solvents pH or temperature
Safety and Handling
- Hazards
- May cause irritation to the skin eyes or respiratory tract
- Proper precautions should be taken to avoid inhalation or ingestion
Handling
- Use appropriate personal protective equipment PPE including gloves goggles and a lab coat
- Work in a fume hood or a wellventilated area
Storage: Store in a cool dry place away from moisture light and strong acids or bases
Synthesis Overview
- The compound is often synthesized by cyclization reactions involving hydrazines and pyridine derivatives under specific conditions
- Reagents like aldehydes acyl chlorides or esters may be used to form the fused system
- Would you like additional details on its synthesis routes specific reactions or pharmacological applications
High Purity & Reliable Quality
This compound surpasses demanding pharmaceutical standards with an assay by HPLC of at least 98% and purity exceeding 99%. Its extremely low impurity profile (NMT 0.5%) along with strict control over particle size and heavy metal content ensures optimal reliability for pharmaceutical manufacturing and research applications.
Safety and Storage
1,2,4-Triazolo[4,3-a]pyridine-3(2H)-one is classified as non-hazardous and non-poisonous under normal handling, making it suitable for standard laboratory and factory environments. To preserve stability and quality, store it in a tightly closed container at 28C in a cool, dry place. The product maintains a stable shelf life of up to two years when properly stored.
Versatile Applications in Drug Synthesis
As an active pharmaceutical ingredient (API) and a vital intermediate, this compound plays a crucial role in the synthesis of various pharmaceuticals. Its versatile solubilityin organic solvents and slight water solubilityallows for flexible formulation development and process adaptation within the pharmaceutical industry.
FAQs of [1,2,4] TRIAZOLO [4,3-A] PYRIDINE-3(2H)-ONE:
Q: How should 1,2,4-Triazolo[4,3-a]pyridine-3(2H)-one be stored for maximum stability?
A: For optimal stability, store the compound in a tightly closed container at 28C in a cool, dry environment. Avoid exposure to direct sunlight and moisture to maintain its shelf life of up to two years.
Q: What are the recommended uses for this compound within the pharmaceutical industry?
A: This substance serves primarily as an intermediate in the synthesis of pharmaceutical products. Its high purity and minimal impurity levels make it ideal for forming the backbone of various active pharmaceutical ingredients (APIs) and advanced intermediates.
Q: When does the product expire and how long will it remain stable?
A: Under recommended storage conditions (28C, dry, tightly sealed container), 1,2,4-Triazolo[4,3-a]pyridine-3(2H)-one remains stable and effective for up to two years from the date of manufacture.
Q: Where is the product manufactured and supplied?
A: This pharmaceutical-grade ingredient is manufactured, supplied, and distributed by reputable companies based in India, and meets all requisite quality and regulatory standards for global distribution.
Q: What packaging is used to ensure product safety during transport?
A: The product is carefully packed in HDPE drums or double polyethylene bags, which provide robust protection against contamination, moisture, and physical damage during both storage and transportation.
Q: What are the benefits of choosing this compound for pharmaceutical synthesis?
A: Customers benefit from its exceptional purity (>99%), low impurity content (0.5%), customizable particle size, and dependable physical stability. These features support consistent quality and performance in pharmaceutical formulations and research.
Q: Is there any health or environmental hazard associated with handling this substance?
A: This compound is considered non-hazardous and non-poisonous under normal laboratory and industrial handling, posing minimal risk to health or the environment when used according to guidelines.
![[1,2,4] TRIAZOLO [4,3-A] PYRIDINE-3(2H)-ONE](https://cpimg.tistatic.com/10214714/b/4/-1-2-4-TRIAZOLO-4-3-A-PYRIDINE-3-2H-ONE.jpg)
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